How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations

Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with adherence, interventions that promote antidepressant pharmacological aspects related and formulates 10 clinical recommendations optimize adherence. Patient-related non-adherence include younger age, psychiatric medical comorbidities, cognitive impairment, substance use Prescriber behavior-related neglecting family histories, selecting poorly tolerated antidepressants, or complex regimens. Multi-disciplinary targeting both patient prescriber, aimed at improving psychoeducation providing clear behavioral prevent/minimize Regarding choice, agents individually tailored tolerability profile should be chosen. Ten four points focusing on (therapeutic alliance, adequate history taking, measurement of symptoms, adverse effects improved access care), three prescribing practice (psychoeducation, simplified regimen), two mental health services (improved care, incentivized promotion monitoring), one relating (adherence scales and/or therapeutic drug monitoring).